USP Method Transfer of Donepezil Tablets from HPLC to UPLC

■ ■ 92% reduction in solvent usage and sample injected in t ro du C t io n Compendial methods are often used in the analysis of generic drugs. Typically, methods are developed and submitted based on a specific formulation. However when the excipients are changed, the method specified in a USP monograph may be inadequate in eluting all components off of the column. The result can be deteriorating peak shape and premature method failure due to a build-up of poorly soluble excipients on the column.